Sunday, 8 January 2012

Researchers discover genetic changes cause cancer of the thyroid gland

Enable U.S. researchers identify 3 of the genetic changes cause cancer, thyroid, and one of these changes shall be known as gene PTEN gene, which increases the risk of children with the disease.

She said Director of the Institute of gene therapy at Cleveland Clinic, Dr. Haraz Inge said: "We have managed the research team to study the genetic changes behind the thyroid disease has resulted in a reach of important details to help diagnose and treat disease, and hope that this study in the early detection of disease and access to the best treatment possible." .

To access the relationship between cancer risk and genetic changes, the researchers examined the follow-up nearly 3 thousand patients each were diagnosed with another disease known Cowden syndrome, a rare disease caused by defective tissue resulting in multiple tumors.

This study focused on mutations in 3 genes, known as PTEN and SDH and KLLN and because the entire work is focused on methods of remote cell therapies should be designed to reduce the risk of cancer targeting each gene separately.

The researchers discovered that mutations gene PTEN are associated with increased risk of thyroid cancer, in addition to signals for mutations other in the genes PTEN and SDH and KLLN may be included in the emergence of the problem as well, but the gene, the first is responsible for injury to children under the age of 18 years of thyroid cancer, and good luck is a test gene PTEN key element in the world of analysis of genes, as confirmed by the study.

The thyroid cancer recorded the largest increase among all other types of cancer that affects both men and women alike, and the PTEN gene is the inhibitor of the tumors and when it is in healthy condition helps in the growth and cell division.

However, inherited mutations of this gene and hinder the function of the gene and Tdjah help in the growth of tumors. This irregularity in the function of this gene is found in about 80% of patients with Cowden syndrome who are at high risk of breast cancer and thyroid.